![]() These regions furthermore showed connectivity with frequency of depersonalization states. In addition, DPRD patients also co-activated the dorsomedial prefrontal cortex (DMPFC BA9) and PCC (BA31), which were also found to be the main between-group difference regions. For basic Stroop to neutral contrast, DPRD patients differed in the location (inferior vs superior lobule) of the parietal region involved, but showed similar activations in the left frontal region. Evoked hemodynamic responses for basic Stroop/Negative Priming activations were compared. DPRD and non-referred control (NC) subjects underwent a combined Stroop/Negative Priming task, and the neural correlates of Stroop Interference Effect, Negative Priming Effect, error rates, cognitive load span, and average amplitude of skin conductance responses were ascertained for both groups. However multimodal neuroimaging and psychophysiology studies have not yet been conducted to test for functional and effective connectivity under cognitive stress in DPRD patients. Previous studies have yielded evidence for cognitive processing abnormalities and alterations of autonomic functioning in Depersonalization-Derealization Disorder (DPRD). Aberrations in fibre tract communication seem to be not solely a secondary effect of local grey matter volume loss, but may present a primary pathophysiology in patients with DPD. In patients with DPD, the structural connectivity between brain regions crucial for multimodal integration and emotion regulation may be altered. Confirmatory replications are necessary to corroborate the results of this explorative investigation. To ensure ecological validity, patients with certain comorbidities or psychotropic medication were included in the study. However, we found a trend for 1 subnetwork that may support the model of frontolimbic dysbalance suggested to underlie DPD symptomatology. Using network-based statistics, no significant results emerged. These links were also associated with dissociative symptom severity and could not be explained by anxiety or depression scores. Our main finding refers to lower FA values within left temporal and right temporoparietal regions in individuals with DPD than in healthy controls when using a link-based controlling procedure. Group differences were assessed using network-based statistics and a link-based controlling procedure. Mean interregional fractional anisotropy (FA) was used to define the network weights. We explored the structural connectome in 23 individuals with DPD and 23 matched, healthy controls by applying graph theory to diffusion tensor imaging data. However, to our knowledge, no research on network characteristics in this patient population exists to date. Such local neuronal changes might be mediated by altered interregional white matter connections. Neuroimaging studies have associated DPD with structural and functional alterations in a variety of distinct brain regions. ![]() Depersonalization/derealization disorder (DPD) is a chronic and distressing condition characterized by detachment from oneself and/or the external world.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |